Design and Development of Sustained Release Swelling Matrix Tablets of Glipizide for Type Ii Diabetes Mellitus
نویسندگان
چکیده
The aim of the present study was to develop a sustained release monolithic system for the low solubile/low dose glipizide, for the treatment of type II diabetes mellitus. The matrices were prepared by dry blending of polymers hydroxy propyl methyl cellulose (HPMC) or erodible Eudragit (ammonio methacrylate copolymers) and other excipients using direct compression method and were characterized using DSC (differential scanning calorimetry), FTIR (Fourier transform infrared spectroscopy), SEM (scanning electron microscopy), drug content, hardness, friability, in vitro dissolution and stability
منابع مشابه
Development of lipid micromatrices based sustained release tablets of glipizide: suitability of stearic acid as release retardant
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